Die Grundprinzipien der kratom
Die Grundprinzipien der kratom
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Kratom is scheduled to become an illegal substance rein Indonesia hinein 2024 once new regulations from the Indonesian National Narcotics Agency (BNN) go into effect.[87] This pending ban has been hinein place since 2019; the date of the ban going into effect welches pushed out to 2024 to give Kratom farmers time to switch to other crops.
rein April 2019, the FDA issued a statement declaring that kratom was not approved for any medical use, was potentially unsafe in commercial products available in the United States, and remained on an import alert where imported supplies would Beryllium confiscated.[11]
NIDA also supports preclinical research to better understand how multiple kratom compounds produce complex pharmacological and behavioral effects, to evaluate kratom as a potential therapy for opioid use disorder and to investigate the chemistry and biology of kratom-derived compounds for their use as therapeutic drugs and as research tools. (See Could kratom Beryllium used as medicine?)
U.S. and international agencies have expressed concern that kratom products may cause serious harm.1 There are no uses for kratom approved by the U.S. Food and Drug Administration (FDA), and the FDA has warned consumers not to use kratom products because of potential adverse effects.
Respiratory depression is the leading cause of death from opioid use.[59] Although evidence is sparse, the risk of respiratory depression caused by taking kratom appears to Beryllium low, but as of 2016[update] the Food and Drug Administration listed respiratory depression as a concern.
Health care professionals and consumers should report any adverse events related to products containing kratom to the FDA’s MedWatch program.
rein 1836, kratom was reported to have been used as an opium substitute hinein Malaysia. Kratom welches also used as an opium substitute in Thailand in the 19th century.[6]
Kratom products in the U.S. are commonly used in doses ranging from 2–6 g of dried leaf vermittels dose, and doses exceeding 8 g are relatively uncommon.[47] Given that kratom products may vary greatly rein potency, there kratom is no standard dosing Gebilde. At relatively low doses (1–5 g of raw leaves), at which there are mostly stimulant effects, side effects include contracted pupils and blushing; adverse effects related to stimulation include anxiety and agitation, and opioid-related effects like itching, nausea, loss of appetite, and increased urination begin to appear.
It has also been promoted to enhance sexual function. It's important to note that none of these uses have been studied clinically or are proven to be safe or effective.
Some research suggests that mitragynine and 7-hydroxymitragynine may not cause some of the more serious adverse effects associated with opioid use—such as respiratory depression (Ärger breathing)—that can occur during a life-threatening opioid overdose.
Kratom products may contain harmful contaminants. There are no uses for kratom approved by the FDA, and kratom products have been found to contain contaminants that produce effects not associated with kratom or kratom compounds alone, including heavy metals and harmful bacteria.
Of particular interest to NIDA, early studies suggest kratom and kratom compounds warrant further study as experimental treatments for substance use disorders, specifically opioid use disorder.9, 48 Such treatments are urgently needed to help curb the drug overdose epidemic hinein the United States.
Currently, kratom is not included in standard drug screens hinein the US. Kratom tests are available for screening but are not widely available.
Mitragynine is classified as a kappa-opioid receptor agonist and is roughly 13 times more potent than morphine. Mitragynine is thought to Beryllium responsible for the opioid-like effects.
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